| The bioactive concentrate is an active substance-aqueous solution
or lyophilized powder-consisting of anti-hyaluronidase and antiinflammatory
mucopolysaccharide polymers and an addition of restitutive and anti-hyaluronidase
chondroitin sulphate, which has a pH=4-6 and antihyaluronidase activity.
The bioactive concentrate producing method consists in a two-phased treatment
of animal-originated connective cartilaginous tissues such as bovine and
sheep trachea, umbilical cord,young animal tendons, bowels, testicles or
sea organisms, with phenol solution and the solution resulting is concentrated
by vacuum evaporation and then defatted; after filtering, the supernatant
obtained is treated for deproteinization, the ion excess is removed by
passing through ion exchanger column, the alcohol solution is concentrated
to remove alcochol until reaching a volume of 70% as against the aqueous
solution subject to proteinization. Drug compositions contain the bioactive
concentrate -solution or in lyophilized state - associated with synergic
substances such as : heparin, sodium or lysinacetylsallicylate, ascorbic
acid, vitamin E,"I"-like structured water, benzyl alcohol, propylene glycocoll,
plant extracts( Achillea, Calendula, Matricaria, Plantago, Hypericum) and
usual excipients, being conditioned in the form of intramuscular or intraarticular
injections, ointment, gel and suppositories. Finally, the histamines are
removed and chondroitin sulphate is added up to the concentration required. |
