|
|
| January 1983 | A pilot plant for structured water was designed in the building
no.18, Dumbrava Rosie St. Bucharest. |
| May 1983 | The pilot plant was put into operation, due to the efforts of Prof.
Dr. Ioan Manzatu, the author of the structured waters invention, patented
in 1981, helped by his colaborator Gheorghe Lucaci and a laboratory
assistant.
|
| 1983-1984 | Based on the first results obtained, a semi-industrial pilot plant
was built and the first application in antibiotics production started at
Iassi Antibiotics Factory. |
| 1985 | The year of the first results at industrial scale, by producing
penicillin with structured water. A biosynthesis rate increase by 55%
was reached. A significant number of outstanding inventions were
patented. |
| 1985-1987 | The period of large experiments with structured waters made on
grain and vegetable crops, pharmaceutical and cosmetic products.
|
| 1987 | The Research Laboratory for Structured Waters was integrated in The
Central Institute for Chemistry. |
| 1987-1990 | Based on research contracts, a profitable cooperation started with
Curtea de Arges Protein Factory (ROMPROTEIN), the only national
producer of bioproteins at industrial scale in Romania.
|
| 1991 | After the revolution (1989), The Centre for Biotechnologies S.A. was set up, originated from the
former Research Laboratory for Structured Water.
|
| 1991-1993 | An intensive R&D activity was carried out by the specialists of
the Centre for Biotechnologies in the fields such as: activated and
structured aqueous solutions, biotechnologies, biologically active
products, fine chemical synthesis products, biochemical synthesis
products, enzymatic biosynthesis products, ecology, pattern recognition
systems, a.s.o. Other important inventions were also
patented. |
| April 1993 | By Governmental Decision no. 146 of April 26, 1993, a new company,
namely BIOTEHNOS S.A. was set up, including the structure of the Centre
for Biotechnologies.
After years of studies, the first pharmaceutical
products, ALFLUTOP® - injectable solution for the treatment of
degenerative rheumatic diseases and ARMON® - cream for the
treatment of burns and wounds caused by different ethiological agents,
natural products based on in-house technologies, were authorized by the
Romanian Ministry of Health. |
| 1994 | A decisive year for BIOTEHNOS. The R&D activity was naturally
followed by practical applications and technology transfer; the new
pharmaceutical and cosmetic products were assimilated into production.
|
| 1995-1997 | In 1995 BIOTEHNOS & TEHMAN ASSOCIATION was set up, aiming
to build up a complex for biotehnological development and industrial
production of biopharmaceuticals and biocosmetics. The financial support
of TEHMAN S.A. for this new and modern investment, ” a state of the
art for the natural medicine industry” as James B. LaValle ,
President of U.S.A Natural Health Resources, Inc. said in his report after
visiting the plant in 1997, reached over 10 million USD. Unfortunately, in
1997 the Romanian Bank for Foreign Trade, actually liquidated, stopped any
financing program for completing the plant (finished 90%), with
demolishing consequences for the activity of the company. |
| 1997 | R&D international cooperation with Hungary and
Greece. Structured waters technology sold to ESTEE LAUDER, USA, the world‘s leader company in cosmetics. Signing of an important agreement with a Chinese company for
establishing a joint venture in Guangzhou, aiming to manufacture natural
pharmaceutical and cosmetic products, based on BIOTEHNOS technologies.
|
| 1998 | Privatisation of BIOTEHNOS S.A (83% Romanian capital, 13%
German capital, 4% Cyprus). December 1998 The invention related to Structured Waters, the main active principle of most BIOTEHNOS natural pharmaceutical and cosmetic products - was granted a patent in the USA, which was followed, in October 1999, by a patent granted also in the USA for the invention related to Bioactive Concentrate, the active principle of ALFLUTOP® - injectable solution. The two inventions have also registered international application for patenting in many other countries, including EU. |
| 1996-1999 | The innovative value of the BIOTEHNOS specialists was highly
appreciated abroad, their inventions and products being rewarded by the
jury of the international exhibitions, such as : 3 gold and 2 bronze
medals at the 24-th International Exhibition of Inventions, Geneve,
1996; 3 gold, 3 silver and 2 bronze medals at the
27-th International Exhibition, Geneve,
1999; 4 gold, 1 silver, 1 bronze medals at ”EUREKA 99”
Bruxelles, 1 gold and one simple at Budapest, Hungary - 1999.
Registration of BIOTEHNOS main pharmaceutical and cosmetic products
abroad. |
| September 1999 | Registration in Venezuela of the FARMOTEHNOS S.A. Venezuelan -
Romanian joint venture. |
| 2000 | The crucial year for BIOTEHNOS, the year of a new strategy aiming to launch BIOTEHNOS as an innovative company in the highly prospective field of biotehnology, with highly efficient implications in the life of society. The signing of new R&D agreements with ESTEE LAUDER - N.Y., GRANT INDUSTRIES - N.J. - USA. |
